| NCT07812805 | SKL35501 With SKL35502 Imaging in Adults With NTSR1 Positive Advanced Solid Tumors | Phase 1 | Recruiting | Aug 19, 2026 | 2030-07 (estimated) |
| NCT05067634 | Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures | Phase 3 | Active, not recruiting | Jan 10, 2022 | 2026-11 (estimated) |
| NCT06453213 | Open-label Study of Cenobamate Monotherapy in Adult Subjects With Newly Diagnosed or Recurrent Partial-Onset Epilepsy | Phase 4 | Active, not recruiting | Oct 14, 2024 | May 26, 2027 (estimated) |
| NCT03678753 | Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in PGTC Seizures | Phase 3 | Completed | Oct 3, 2018 | May 26, 2025 (actual) |
| NCT03961568 | Cenobamate Open-Label Extension Study for YKP3089C025 | Phase 3 | Completed | Aug 13, 2019 | Jun 10, 2026 (actual) |
| NCT04557085 | Randomized, Double-blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in POS | Phase 3 | Completed | Mar 8, 2021 | Feb 16, 2024 (actual) |
| NCT04903314 | Dose-Escalation Study of Cenobamate (YKP3089) in Pediatric Subjects With Partial-Onset Seizures | Phase 1 | Completed | May 27, 2021 | Nov 6, 2025 (actual) |
| NCT05219617 | Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults | Phase 3 | Recruiting | Apr 28, 2022 | 2027-02 (estimated) |
| NCT01866111 | A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures | 2 | Completed | Jul 31, 2013 | Apr 5, 2021 (actual) |
| NCT05388435 | Safety, Tolerability, PK/PD & Preliminary Efficacy of SKL27969 in Advanced Solid Tumors Patients | Phase 1/Phase 2 | Terminated | Sep 12, 2022 | Mar 1, 2024 (actual) |
| NCT03509285 | A Study of the Abuse Liability Potential of Cenobamate in Recreational Drug Users | Phase 1 | Completed | Mar 8, 2017 | Nov 18, 2017 (actual) |
| NCT05572255 | A Randomized, Open-label, Three-way Crossover Study to Evaluate the Relative Bioavailability of 200 Mg Cenobamate Administered Orally | Phase 1 | Completed | Sep 27, 2022 | Jan 28, 2023 (actual) |
| NCT03234699 | Assess the Influence of Cenobamate on the PK of Cytochrome P450 (CYP) Probe Drugs As a Means of Predicting Drug-drug Interactions | Phase 1 | Completed | Feb 22, 2017 | Jul 3, 2017 (actual) |
| NCT04690751 | Bioavailability and Food Effect Study of Cenobamate as an Oral Suspension and Tablet | Phase 1 | Completed | Dec 21, 2020 | May 17, 2021 (actual) |
| NCT02535091 | Safety and Pharmacokinetic Study of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures | Phase 3 | Completed | Aug 3, 2016 | Mar 31, 2021 (actual) |
| NCT04062981 | Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut Syndrome | Phase 1 | Completed | May 3, 2019 | Dec 14, 2022 (actual) |
| NCT04791553 | Safety Study of Cenobamate in Subjects With Normal Hepatic Function and Subjects With Severe Hepatic Impairment | Phase 1 | Completed | Jun 17, 2021 | Nov 15, 2022 (actual) |
| NCT04505397 | Single-Dose Escalation Study Followed by a Multiple-Dose Escalation Study of SKL24741 in Healthy Subjects | Phase 1 | Completed | Feb 13, 2020 | Oct 27, 2022 (actual) |
| NCT03731715 | Carisbamate in Adult & Pediatric Subjects With Lennox-Gastaut Syndrome | Phase 1 | Completed | Feb 7, 2019 | May 23, 2022 (actual) |
| NCT01397968 | Efficacy and Safety of YKP3089 in Subjects With Treatment Resistant Partial Onset Seizures | Phase 2 | Completed | Jul 6, 2011 | 2013-06 (actual) |
| NCT04513860 | Cenobamate Expanded Access Program (EAP) | Not listed | Approved for marketing | Not listed | Not listed |
| NCT04520360 | Bioavailability and Food Effect Study of 3 Types of Carisbamate | Phase 1 | Completed | Aug 27, 2020 | Oct 6, 2021 (actual) |
| NCT00492323 | An Effectiveness and Safety Study With RWJ-333369 (Carisbamate) for the Study of Postherpetic Neuralgia (PHN). | Phase 2 | Completed | 2007-03 | 2008-06 (actual) |
| NCT00501202 | Study for Safety and Effectiveness of RWJ-333369 (Carsibamate) for the Treatment of Diabetic Peripheral Neuropathy (DPN). | Phase 2 | Completed | 2007-03 | 2008-05 (actual) |
| NCT02205099 | A Safety, Tolerability, PK and PD Study of Multiple Oral Doses of SKL15508 in Subjects With Stable Schizophrenia | Phase 1/Phase 2 | Completed | 2014-07 | 2015-06 (actual) |
| NCT01521598 | A Phase 2, Multicenter, Randomized, Double-blind, Placebo Controlled Study for the Pain of Diabetic Peripheral Neuropathy | 2 | Completed | 2012-01 | 2013-06 (actual) |
| NCT01989234 | A Multicenter, Double-Blind, Randomized, Placebo-Controlled, 12-Week, Dose-Range-Finding Trial of YKP10811 Capsules Administered Once Daily to Subjects With Chronic Idiopathic Constipation | Phase 2 | Completed | 2013-10 | 2014-09 (actual) |
| NCT01523184 | A Phase 2 Study to Evaluate Pharmacodynamics of YKP10811 in Patients With Chronic or Functional Constipation | 2 | Completed | 2012-03 | 2013-11 (actual) |
| NCT00616148 | Efficacy of YKP3089 in Patients With Photosensitive Epilepsy | Phase 2 | Completed | 2007-08 | 2009-01 (actual) |
| NCT00991757 | An Open-Label Extension Study to Evaluate the Safety and Tolerability of RWJ 333369 as Adjunctive Therapy in Patients 16 Years and Older With Partial Onset Seizures. | Phase 3 | Completed | 2007-02 | 2010-10 (actual) |
| NCT00744731 | An Open-Label Extension Study of the Safety and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures | Phase 3 | Completed | 2009-01 | 2010-08 (actual) |
| NCT00563459 | Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-epileptic Drugs (AEDs) in Patients With Epilepsy. | Phase 3 | Terminated | 2007-11 | 2010-04 (actual) |
| NCT00210522 | An Open-Label Extension Study of the Effectiveness and Safety of the Investigational Compound RWJ-333369 in Patients With Epilepsy | Phase 2 | Completed | 2005-05 | 2010-06 (actual) |
| NCT00524056 | A Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential Tremor | Phase 2 | Completed | 2007-08 | 2008-03 (actual) |
| NCT00870454 | An Efficacy and Safety Study of Carisbamate in the Treatment of Nerve Pain in Diabetics | Phase 2 | Completed | 2009-05 | 2010-12 (actual) |
| NCT00740623 | A Study of the Effectiveness, Safety, and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures. | Phase 3 | Completed | 2009-01 | 2009-10 (actual) |
| NCT00210652 | An Open-Label Extension Study to Evaluate the Safety and Effectiveness of RWJ 333369 in Patients With Epilepsy | Phase 2 | Completed | 2004-07 | 2010-03 (actual) |
| NCT00697762 | Effectiveness and Safety Study for RWJ-333369 as Adjunctive Therapy in Korean and Japanese Patients With Partial Onset Seizures | Phase 3 | Terminated | 2007-10 | 2008-05 (actual) |
| NCT00697918 | Long Term Effectiveness and Safety Study for RWJ-333369 as Adjunctive Therapy in Korean and Japanese Patients With Partial Onset Seizures | Phase 3 | Completed | 2008-03 | 2009-04 (actual) |
| NCT00109083 | A Study of the Efficacy of RWJ-333369 in the Prevention of Migraine | Phase 2 | Completed | 2002-03 | 2006-02 (actual) |
| NCT00228969 | Safety and Efficacy of 333369 in the Treatment of Partial Epilepsy | Phase 2 | Completed | 2005-02 | 2006-05 (actual) |
| NCT00425282 | A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures. | Phase 3 | Completed | 2006-11 | 2007-10 (actual) |
| NCT00433667 | A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures. | Phase 3 | Completed | 2006-11 | 2007-10 (actual) |
