COMPANY

GRIN Therapeutics

Keywords: tuberous sclerosis Focal Cortical Dysplasia Tuberous Sclerosis Complex Other Neurological Disorders GRIN-related Neurodevelopmental Disorder Hepatic Impairment GRIN-related Disorders Radiprodil

Profile checked Oct 10, 2026

6Trials (company is sponsor)

Timeline

Mar 3, 2026 Trial start Phase 1: Radiprodil in Participants With Hepatic Impairment source ↗
Jan 5, 2026 Trial start 3: Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder source ↗
May 20, 2025 Trial start 1: Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs. source ↗
May 8, 2025 Trial start Phase 1: Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults source ↗
Jul 10, 2024 Trial start Phase 1/Phase 2: Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II source ↗
Mar 7, 2023 Trial start Phase 1: Honeycomb: Evaluation of Radiprodil in Children with GRIN-related Disorder source ↗

Upcoming milestones

2026-11 (ESTIMATED) · Phase 1 · Honeycomb: Evaluation of Radiprodil in Children with GRIN-related Disorder · NCT05818943
2027-05 (ESTIMATED) · 3 · Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder · NCT07224581
2027-05 (ESTIMATED) · Phase 1 · Radiprodil in Participants With Hepatic Impairment · NCT07457229

Estimated primary completion per ClinicalTrials.gov. Dates move.

Clinical trials (lead sponsor) 6

Record	Title	Phase	Status	Start	Primary completion
NCT07224581	Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder	3	Recruiting	Jan 5, 2026	2027-05 (estimated)
NCT07457229	Radiprodil in Participants With Hepatic Impairment	Phase 1	Recruiting	Mar 3, 2026	2027-05 (estimated)
NCT06392009	Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II	Phase 1/Phase 2	Active, not recruiting	Jul 10, 2024	2026-06 (estimated)
NCT06965881	Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults	Phase 1	Terminated	May 8, 2025	Jul 8, 2025 (actual)
NCT06975605	Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs.	1	Completed	May 20, 2025	Jul 10, 2025 (actual)
NCT05818943	Honeycomb: Evaluation of Radiprodil in Children with GRIN-related Disorder	Phase 1	Active, not recruiting	Mar 7, 2023	2026-11 (estimated)