COMPANY

Rose Research Center

HQ: Raleigh, NC source · roseresearchcenter.com ↗

Location: Raleigh, NC · source · Oct 15, 2026

Profile checked Oct 10, 2026

Keywords: Smoking Cessation Harm Reduction Cigarette Smoking E-Cig Use Tobacco Dependence Tobacco Use Cessation Stress Sleep Disturbance Nausea Nicotine Addiction Tobacco Use Tobacco Use Disorder d-cycloserine Varenicline EMB-01

13Trials (company is sponsor)

Timeline

Aug 29, 2024 Trial start Phase 3: Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders source ↗
Dec 27, 2023 Trial start Phase 3: Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT source ↗
Oct 20, 2023 Trial start Phase 2: Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine source ↗
Feb 14, 2023 Trial start Not phased (device or behavioral study): Exploratory Study of Switching From Combustible Cigarettes to the BIDI E-cigarette source ↗
Dec 14, 2021 Trial start Phase 3: The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette source ↗
May 19, 2021 Trial start Phase 2/Phase 3: Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment source ↗
Mar 22, 2021 Trial start —: A Comparison of Exhaled Carbon Monoxide Measurements Using the iCOquit Smokerlyzer and Vitalograph Breath CO Monitor vs Carboxyhemoglobin From Venous Samples While Validating a Mobile Research Appl source ↗
May 27, 2020 Trial start Phase 3: Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes source ↗
Jan 30, 2020 Trial start —: Comparative Tobacco Interventions for Individuals With Severe and Persisting Behavioral Health Disorders source ↗
Nov 19, 2019 Trial start Phase 2/Phase 3: Combination of E-cigarettes and Varenicline for Tobacco Harm Reduction source ↗
Aug 26, 2019 Trial start Not phased (device or behavioral study): Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes source ↗
Jun 17, 2019 Trial start Phase 4: Efficacy and Tolerability of Combination Varenicline With Hydroxyzine as a Potential Smoking Cessation Treatment source ↗
May 1, 2019 Trial start Phase 2: Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use source ↗

Clinical trials (lead sponsor) 13

Record	Title	Phase	Status	Start	Primary completion
NCT06554873	Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders	Phase 3	Completed	Aug 29, 2024	Dec 9, 2025 (actual)
NCT05205811	The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette	Phase 3	Completed	Dec 14, 2021	Jun 19, 2025 (actual)
NCT05994703	Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine	Phase 2	Completed	Oct 20, 2023	Oct 13, 2025 (actual)
NCT04188197	Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes	Not phased (device or behavioral study)	Completed	Aug 26, 2019	Mar 2, 2021 (actual)
NCT06088862	Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT	Phase 3	Terminated	Dec 27, 2023	Apr 30, 2024 (actual)
NCT05855343	Exploratory Study of Switching From Combustible Cigarettes to the BIDI E-cigarette	Not phased (device or behavioral study)	Completed	Feb 14, 2023	Sep 5, 2023 (actual)
NCT04188106	Efficacy and Tolerability of Combination Varenicline With Hydroxyzine as a Potential Smoking Cessation Treatment	Phase 4	Completed	Jun 17, 2019	Dec 15, 2019 (actual)
NCT04388319	Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes	Phase 3	Completed	May 27, 2020	Jun 4, 2021 (actual)
NCT04210180	Combination of E-cigarettes and Varenicline for Tobacco Harm Reduction	Phase 2/Phase 3	Completed	Nov 19, 2019	Oct 14, 2020 (actual)
NCT02870218	Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use	Phase 2	Completed	May 1, 2019	Jul 28, 2021 (actual)
NCT04826549	A Comparison of Exhaled Carbon Monoxide Measurements Using the iCOquit Smokerlyzer and Vitalograph Breath CO Monitor vs Carboxyhemoglobin From Venous Samples While Validating a Mobile Research Application	Not listed	Completed	Mar 22, 2021	Oct 27, 2021 (actual)
NCT04523948	Comparative Tobacco Interventions for Individuals With Severe and Persisting Behavioral Health Disorders	Not listed	Unknown status (ClinicalTrials.gov)	Jan 30, 2020	Oct 31, 2022 (estimated)
NCT04868253	Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment	Phase 2/Phase 3	Unknown status (ClinicalTrials.gov)	May 19, 2021	Dec 31, 2021 (estimated)