Location: San Francisco, CA · source · Oct 14, 2026
Profile checked Oct 10, 2026
Keywords: Metastatic Breast CancerBreast CancerER Positive Breast CancerLocally Advanced Breast CancerHER2 Negative Breast CarcinomaHER2-negative Breast CancerAdvanced or Metastatic ER+ HER2- Breast Cancer (mBC)Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)Advanced or Metastatic Castration-Resistant Prostate Cancer (mCRPC)FulvestrantPalazestrantAdvanced Breast CancerHormone Receptor Positive Breast CarcinomaOP-3136OP-1250
Board tracked Radar started tracking this company’s job board (23 open jobs at last check). source ↗
Trial start Phase 3: Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer source ↗
Trial start 1: Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors source ↗
Trial start Phase 3: OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer source ↗
Trial start 1: Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer source ↗
Trial start 1: A Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer Patients source ↗
Trial start Phase 1/Phase 2: A Dose Escalation/Expansion Study of Oral OP-1250 in Subjects With Advanced and/or Metastatic HR+, HER2- Breast Cancer source ↗
Upcoming milestones
Oct 31, 2026 (ESTIMATED) · Phase 3 · OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer · NCT06016738
May 30, 2027 (ESTIMATED) · 1 · Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors · NCT06784193
Dec 31, 2027 (ESTIMATED) · 1 · Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer · NCT05508906
2028-12 (ESTIMATED) · Phase 3 · Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer · NCT07085767
Estimated primary completion per ClinicalTrials.gov. Dates move.
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