COMPANY

Enzyme by Design

HQ: Chicago, IL source · enzymebydesign.com ↗ · Midwest

Keywords: oncology cancer

Location: Chicago, IL · source · Oct 15, 2026

Profile checked Oct 10, 2026

10NIH grants

Funding and NIH signals

NIH award NIH awarded $400K (SBIR Phase I 1R43CA306391-01A1, new, notice Sep 16, 2026). NIH RePORTER 1R43CA306391-01A1 (Sep 16, 2026)
Evidence (1 event)
- Sep 16, 2026 · NIH RePORTER 1R43CA306391-01A1
  Organization: ENZYME BY DESIGN, INC.; City/State: CHICAGO, IL; Project number: 1R43CA306391-01A1; Activity code: R43; Fiscal year: 2026; Award notice date: 2026-09-16; FY total cost (award amount): 400000; Administering IC: National Cancer Institute; Project title: Validating the reduced immunogenicity of novel human-like asparaginases to de-risk clinical development; Organization type: Domestic For-Profits

Job counts as of Oct 18, 2026. All funding and NIH signals

Timeline

Sep 16, 2026 Grant Government grant — SBIR: $400,000 (annual award, as published), announced Sep 16, 2026. Agency: NIH/NCI. Source: government award database. source ↗

Funding

Last 2 years.

Sep 16, 2026 Government grant — SBIR: $400,000 (annual award, as published), announced Sep 16, 2026. Agency: NIH/NCI. Source: government award database. source ↗

NIH awards 10

Annual award amounts. Total $3.9M.

Jul 5, 2024 NIH award 1R43CA291296-01 FY2024: $400,000 awarded for that fiscal year; activity R43 (SBIR); PI SCHALK, AMANDA M; recipient as written: ENZYME BY DESIGN, INC., CHICAGO, IL. Engineering in vivo half-life extension of source ↗
Aug 4, 2022 NIH award 5R44CA228622-04 FY2022: $836,804 awarded for that fiscal year; activity R44 (SBIR); PI SCHALK, AMANDA M; recipient as written: ENZYME BY DESIGN, INC., CHICAGO, IL. A novel glutaminase-free mammalian asparag source ↗
Aug 24, 2021 NIH award 5R44CA228622-03 FY2021: supplement or administrative line (under $1,000); activity R44 (SBIR); PI SCHALK, AMANDA M; recipient as written: ENZYME BY DESIGN, INC., CHICAGO, IL. A novel glutaminase-free mammalian asparaginase source ↗
Sep 11, 2020 NIH award 2R44CA228622-02 FY2020: $1,156,734 awarded for that fiscal year; activity R44 (SBIR); PI SCHALK, AMANDA M; recipient as written: ENZYME BY DESIGN, INC., CHICAGO, IL. A novel glutaminase-free mammalian aspar source ↗
Aug 31, 2020 NIH award 1R43CA232798-01A1 FY2020: $399,999 awarded for that fiscal year; activity R43 (SBIR); PI SCHALK, AMANDA M; recipient as written: ENZYME BY DESIGN, INC., CHICAGO, IL. Extending the in vivo half-life of a nov source ↗
Jul 14, 2020 NIH award 3R43CA243759-01S1 FY2020: $149,999 awarded for that fiscal year; activity R43 (SBIR); PI SCHALK, AMANDA M; recipient as written: ENZYME BY DESIGN, INC., CHICAGO, IL. Maximizing the safety profile of a novel source ↗
Jul 5, 2019 NIH award 1R43CA243759-01 FY2019: $299,939 awarded for that fiscal year; activity R43 (SBIR); PI SCHALK, AMANDA M; recipient as written: ENZYME BY DESIGN, INC., CHICAGO, IL. Maximizing the safety profile of a novel c source ↗
Feb 4, 2019 NIH award 3R41CA228622-01S1 FY2019: $55,000 awarded for that fiscal year; activity R41 (STTR); PI NGUYEN, HIEN-ANH; recipient as written: ENZYME BY DESIGN, INC., CHICAGO, IL. A novel glutaminase-free mammalian aspara source ↗
Sep 20, 2018 NIH award 1R41CA235796-01 FY2018: $299,552 awarded for that fiscal year; activity R41 (STTR); PI SCHALK, AMANDA M; recipient as written: ENZYME BY DESIGN, INC., CHICAGO, IL. Development of a novel safe and efficaciou source ↗
Apr 16, 2018 NIH award 1R41CA228622-01 FY2018: $298,305 awarded for that fiscal year; activity R41 (STTR); PI NGUYEN, HIEN-ANH; recipient as written: ENZYME BY DESIGN, INC., CHICAGO, IL. A novel glutaminase-free mammalian asparag source ↗