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NicOx

HQ: Biot Sophia Antipolis, France source · nicox.com ↗

Past trials only

Our ophthalmic pipeline also includes a candidate under preclinical evaluation for development in retinal conditions, NCX 1728. From company website Source · Oct 13, 2026

Keywords: preclinical ophthalmic Viral Conjunctivitis Osteoarthritis Hypertension Adenoviral Conjunctivitis Renal Hemodynamics Liver Disease Hip Osteoarthritis Renal Failure naproxcinod

Location: Biot, France · source · Oct 12, 2026

Other sites: Durham, NC (US office) source

Profile checked Oct 10, 2026

15Trials (company is sponsor)

Timeline

  1. Raise Private equity round: €4M (up to, as announced), announced Jan 5, 2026. Source: company release on GlobeNewswire. source ↗
  2. Partnership Partnership / licensing announced Sep 4, 2025. Source: company release on GlobeNewswire. source ↗
  3. Trial start Phase 2: Efficacy and Safety of Iota-Carrageenan Eye Drops (NCX-4240) source ↗
  4. Trial start —: ADenoVirus Initiative Study in Epidemiology in UK source ↗
  5. Trial start —: ADenoVirus Initiative Study in Epidemiology in Italy source ↗
  6. Trial start —: ADenoVirus Initiative Study in Epidemiology in Spain source ↗
  7. Trial start —: ADenoVirus Initiative Study in Epidemiology in Germany source ↗
  8. Trial start —: ADenoVirus Initiative Study in Epidemiology in France source ↗
  9. Trial start Phase 1: Pharmacokinetics Study: Determination of Naproxcinod and Its Metabolites After Oral Administration in Male source ↗
  10. Trial start Phase 1: Effect of Repeated Dosing of Naproxcinod on Renal Hemodynamic and on Sodium Balance in Healthy Volunteers Before and After a Single Dose of Furosemide source ↗
  11. Trial start Phase 1: A Pharmacokinetics and Safety Study of Naproxcinod in Subjects With Impaired Renal Function source ↗
  12. Trial start Phase 1: A Study to Assess the Effects of Naproxcinod and Naproxen on Blood Pressure Measurements in Osteoarthritis Patients With Controlled High Blood Pressure source ↗
  13. Trial start Phase 1: To Assess the Effect of Naproxcinod Versus Naproxen and Ibuprofen on Arterial Blood Pressure in Osteoarthritis Patients With Controlled Essential Hypertension source ↗
  14. Trial start 1: A Phase 1 Study to Compare the PK and Safety of Naproxcinod in Hepatic Impaired Patients and Matching Healthy Subjects source ↗
  15. Trial start Phase 3: Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Hip source ↗
  16. Trial start Phase 3: Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee source ↗
  17. Trial start Phase 3: Analgesic Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee source ↗

Funding

Raised: amount not published. Last 2 years.

Clinical trials (lead sponsor) 15

RecordTitlePhaseStatusStartPrimary completion
NCT03009799Efficacy and Safety of Iota-Carrageenan Eye Drops (NCX-4240)Phase 2Withdrawn2017-012017-08 (estimated)
NCT03055065ADenoVirus Initiative Study in Epidemiology in ItalyNot listedCompleted2014-112015-10 (actual)
NCT02054273ADenoVirus Initiative Study in Epidemiology in GermanyNot listedCompleted2014-042015-06 (actual)
NCT02254330ADenoVirus Initiative Study in Epidemiology in SpainNot listedCompleted2014-072015-08 (actual)
NCT02112773ADenoVirus Initiative Study in Epidemiology in UKNot listedCompleted2015-022015-06 (actual)
NCT02054234ADenoVirus Initiative Study in Epidemiology in FranceNot listedCompleted2013-062014-12 (actual)
NCT01404598Pharmacokinetics Study: Determination of Naproxcinod and Its Metabolites After Oral Administration in MalePhase 1Completed2010-012010-02 (actual)
NCT00909519Effect of Repeated Dosing of Naproxcinod on Renal Hemodynamic and on Sodium Balance in Healthy Volunteers Before and After a Single Dose of FurosemidePhase 1Completed2009-012009-04 (actual)
NCT00621881A Phase 1 Study to Compare the PK and Safety of Naproxcinod in Hepatic Impaired Patients and Matching Healthy Subjects1Completed2008-012008-04 (actual)
NCT00542555Analgesic Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the KneePhase 3Completed2005-12Not listed
NCT00662610A Study to Assess the Effects of Naproxcinod and Naproxen on Blood Pressure Measurements in Osteoarthritis Patients With Controlled High Blood PressurePhase 1Completed2008-032008-08 (actual)
NCT00504127Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the KneePhase 3Completed2007-042008-12 (actual)
NCT00662896To Assess the Effect of Naproxcinod Versus Naproxen and Ibuprofen on Arterial Blood Pressure in Osteoarthritis Patients With Controlled Essential HypertensionPhase 1Completed2008-032008-09 (actual)
NCT00541489Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the HipPhase 3Completed2007-062008-09 (actual)
NCT00674856A Pharmacokinetics and Safety Study of Naproxcinod in Subjects With Impaired Renal FunctionPhase 1Completed2008-052008-09 (actual)

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