COMPANY

Allodynic Therapeutics

Allodynic Therapeutics, Inc is a clinical-stage pharmaceutical company focused on developing naltrexone-acetaminophen combination for treating acute migraine and co-occurring anxiety. The company has completed four investigator-initiated clinical trials that have provided promising results in treati From company website Source · Oct 12, 2026

Keywords: Migraine With or Without Aura Chronic Low Back Pain Lumbar Radiculopathy Migraine With and Without Aura Atypical Facial Pain Persistent Idiopathic Facial Pain Atypical Trigeminal Neuralgia Neuropathic Orofacial Pain Neuropathic Facial Pain ATNC05

Profile checked Oct 10, 2026

7Trials (company is sponsor)

Timeline

Jan 31, 2025 Trial start 2: Single-Site Study of Naltrexone/Acetaminophen for the Acute Treatment of Migraine: A Phase 2 Randomized Trial source ↗
Aug 25, 2017 Trial start Phase 2: The Preventive Treatment of Migraine With Low-Dose Naltrexone and Acetaminophen Combination source ↗
Aug 15, 2017 Trial start Phase 2: Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4) source ↗
Jun 27, 2017 Trial start Phase 2/Phase 3: Low-Dose Naltrexone and Acetaminophen Combination and Sumatriptan in the Acute Treatment of Migraine With Nausea source ↗
Feb 18, 2017 Trial start Phase 2: An Acute Migraine Factorial Study source ↗
Feb 18, 2017 Trial start Phase 2: Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of Migraine source ↗
2014-03 Trial start Phase 2/Phase 3: Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain source ↗

Clinical trials (lead sponsor) 7

Record	Title	Phase	Status	Start	Primary completion
NCT05685225	Single-Site Study of Naltrexone/Acetaminophen for the Acute Treatment of Migraine: A Phase 2 Randomized Trial	2	Withdrawn	Jan 31, 2025	Dec 2, 2025 (actual)
NCT03194555	The Preventive Treatment of Migraine With Low-Dose Naltrexone and Acetaminophen Combination	Phase 2	Completed	Aug 25, 2017	Jul 26, 2018 (actual)
NCT06245902	An Acute Migraine Factorial Study	Phase 2	Completed	Feb 18, 2017	Feb 8, 2018 (actual)
NCT03201393	Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)	Phase 2	Completed	Aug 15, 2017	Jul 26, 2018 (actual)
NCT03061734	Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of Migraine	Phase 2	Completed	Feb 18, 2017	Feb 8, 2018 (actual)
NCT03185143	Low-Dose Naltrexone and Acetaminophen Combination and Sumatriptan in the Acute Treatment of Migraine With Nausea	Phase 2/Phase 3	Completed	Jun 27, 2017	May 7, 2018 (actual)
NCT01920087	Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain	Phase 2/Phase 3	Withdrawn	2014-03	2016-03 (estimated)