COMPANY

Antidote Therapeutics

HQ: Sykesville, MD source · antidotetx.com ↗ · Mid-Atlantic

Antidote Therapeutics, a science-driven biopharmaceutical company focused on developing nicotine-blocking therapies to treat diseases caused or worsened by nicotine. From company website Source · Oct 12, 2026

Keywords: Thromboangiitis Obliterans (Buerger's Disease) ATI-1013

Profile checked Oct 10, 2026

1Trials (company is sponsor)7NIH grants

Timeline

2025-10 Trial start Phase 1: A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers source ↗

Clinical trials (lead sponsor) 1

Record	Title	Phase	Status	Start	Primary completion
NCT07215923	A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers	Phase 1	Recruiting	2025-10	Jun 30, 2026 (estimated)

NIH awards 7

Annual award amounts. Total $21.8M.

Apr 23, 2025 NIH award 5U01DA058547-03 FY2025: $3,883,739 awarded for that fiscal year; activity U01 (OTHER_NIH); PI KALNIK, MATTHEW W; recipient as written: ANTIDOTE THERAPEUTICS, INC., SYKESVILLE, MD. IND-enabling Studies in Su source ↗
Apr 25, 2024 NIH award 5U01DA058547-02 FY2024: $5,215,321 awarded for that fiscal year; activity U01 (OTHER_NIH); PI KALNIK, MATTHEW W; recipient as written: ANTIDOTE THERAPEUTICS, INC., SYKESVILLE, MD. IND-enabling Studies in Su source ↗
Apr 24, 2023 NIH award 1U01DA058547-01 FY2023: $4,026,705 awarded for that fiscal year; activity U01 (OTHER_NIH); PI KALNIK, MATTHEW W; recipient as written: ANTIDOTE THERAPEUTICS, INC., SYKESVILLE, MD. IND-enabling Studies in Su source ↗
Mar 13, 2017 NIH award 1R43DA044064-01 FY2017: $200,834 awarded for that fiscal year; activity R43 (SBIR); PI KALNIK, MATTHEW W; recipient as written: ANTIDOTE THERAPEUTICS, INC., SYKESVILLE, MD. Protein Engineering of a Biologic source ↗
Jul 25, 2016 NIH award 5R01DA038877-03 FY2016: $2,939,717 awarded for that fiscal year; activity R01 (OTHER_NIH); PI KALNIK, MATTHEW W; recipient as written: ANTIDOTE THERAPEUTICS, INC., SYKESVILLE, MD. Lead Optimization and Prec source ↗
Jul 20, 2015 NIH award 5R01DA038877-02 FY2015: $2,960,853 awarded for that fiscal year; activity R01 (OTHER_NIH); PI KALNIK, MATTHEW W; recipient as written: ANTIDOTE THERAPEUTICS, INC., SYKESVILLE, MD. Lead Optimization and Prec source ↗
Sep 15, 2014 NIH award 1R01DA038877-01 FY2014: $2,553,038 awarded for that fiscal year; activity R01 (OTHER_NIH); PI KALNIK, MATTHEW W; recipient as written: ANTIDOTE THERAPEUTICS, INC., SYKESVILLE, MD. Lead Optimization and Prec source ↗