COMPANY

Vantive

FDA-cleared device company Clinical Phase 3

Keywords: renal Acute Kidney Injury End Stage Renal Disease Chronic Kidney Disease Chronic Kidney Failure Diabetes ESRD Regional Citrate Anticoagulation Continuous Renal Replacement Therapy Renal Insufficiency Chronic Renal Disease Acute Kidney Failure Renal Failure Renal Failure Chronic Requiring Hemodialysis Systemic Inflammatory Response Syndrome Hemodialysis Acute Respiratory Distress Syndrome Chronic Renal Failure Acute Renal Failure Mild to Moderate Acute Respiratory Distress Syndrome Congestive Heart Failure Continuous Ambulatory Peritoneal Dialysis AKI - Acute Kidney Injury CKD Liver Failure Inflammation Chronic Inflammation Rhabdomyolysis Sepsis Cardiovascular Disease PrismaLung+ Prismaflex HF20

Profile checked Oct 10, 2026

55Trials (company is sponsor)

Timeline

Jun 17, 2026 Trial start —: Clinical Effectiveness and Resource Use in End-Stage Renal Disease Patients: Remote Patient Monitoring Across Dialysis Modalities source ↗
Dec 11, 2025 Trial start Not phased (device or behavioral study): A Study of the Efficacy and Safety of Extracorporeal Carbon Dioxide Removal Using PrismaLung+ source ↗
Dec 11, 2024 Trial start —: Retrospective Analysis of Prismaflex HF20 Set Versus ppCRRT Registry source ↗
Oct 23, 2024 Trial start —: Registry of Pre-mixed Solutions in Critically Ill Patients on the Continuous Renal Replacement Therapy source ↗
Jul 12, 2024 Trial start Phase 3: Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT source ↗
Jun 28, 2024 Trial start —: Observational Study of the Use of Extraneal in Peritoneal Dialysis in Patients source ↗
Dec 7, 2023 Trial start —: A Post-Market Clinical Performance and Safety Evaluation of GamCath HighFlow Dolphin Protect Catheter source ↗
Jun 22, 2022 Trial start Not phased (device or behavioral study): Theranova Randomized, Controlled, Trial (RCT) in China source ↗
Apr 30, 2021 Trial start Not phased (device or behavioral study): Post-Market Study of Low-flow ECCO2R Using PrismaLung+ source ↗
Jan 22, 2019 Trial start Not phased (device or behavioral study): Clinical Observation of the Performance of Artis Dialysis System, ArtiSet PrePost and Ultra HDF Line in Treatments of Patients With End-Stage Renal Disease (ESRD) source ↗
Dec 20, 2018 Trial start Not phased (device or behavioral study): Performance Evaluation of the AMIA APD Solution Generation System in Patients End Stage Renal Disease (ESRD) source ↗
Sep 14, 2018 Trial start Not phased (device or behavioral study): Study in End Stage Renal Disease (ESRD) Patients on Hemodialysis to Determine Non-inferiority of the Theranova Dialyzer Compared to the FX80 Dialyzer source ↗
Jun 29, 2018 Trial start Not phased (device or behavioral study): Study in End Stage Renal Disease (ESRD) Patients on Hemodialysis Comparing the Theranova Dialyzer to Hemodiafiltration source ↗
Apr 11, 2018 Trial start Not phased (device or behavioral study): Exploratory Study to Explore the Safety and Efficacy of the HDx Therapy Using Theranova 500 Dialyzer in Comparison to Hemodiafiltration source ↗
Sep 29, 2017 Trial start Not phased (device or behavioral study): Theranova 400 Dialyzer In End Stage Renal Disease (ESRD) Patients source ↗
Sep 27, 2016 Trial start Phase 3: Clinical Evaluation of Use of Prismocitrate 18 in Patients Undergoing Acute Continuous Renal Replacement Therapy (CRRT) source ↗
2016-03 Trial start Not phased (device or behavioral study): Automated Setting of Individualized Sodium Technology source ↗
Nov 10, 2015 Trial start Not phased (device or behavioral study): Prismaflex HF20 Set and Prismaflex® System 7.10/7.20 for Acute Continuous Renal Replacement Therapy (CRRT) in Children source ↗
2015-03 Trial start Not phased (device or behavioral study): Comparison of the Clinical Performance of 3 THERANOVA 400 Dialyzer Prototypes With a High-Flux Dialyzer in Hemodialysis Mode source ↗
2015-02 Trial start Not phased (device or behavioral study): Clinical Performance Comparison of 2 THERANOVA 400 Dialyzer Prototypes in HD With High-Flux Dialyzers in HD and hv HDF Mode source ↗
Mar 26, 2014 Trial start Phase 4: Quality of Life on Peritoneal Dialysis Versus Hemodialysis in China source ↗
2014-02 Trial start Not phased (device or behavioral study): PERCI- Medium Cut Off (MCO) source ↗
2012-11 Trial start Not phased (device or behavioral study): Performance Comparison of Revaclear With Larger Dialyzer source ↗
2012-10 Trial start Not phased (device or behavioral study): Evaluation of Evodial Hemodialyzer Selectivity Modifications (Evodial +) source ↗
2012-05 Trial start Not phased (device or behavioral study): HemoControl System Activated in Hemodiafiltration Treatments source ↗

Showing 25 of 50 dated events.

Upcoming milestones

2027-01 (ESTIMATED) · Phase 3 · Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT · NCT05399537
Jan 31, 2027 (ESTIMATED) · Not phased · A Study of the Efficacy and Safety of Extracorporeal Carbon Dioxide Removal Using PrismaLung+ · NCT07326215
Jun 30, 2029 (ESTIMATED) · · Clinical Effectiveness and Resource Use in End-Stage Renal Disease Patients: Remote Patient Monitoring Across Dialysis Modalities · NCT07781124

Estimated primary completion per ClinicalTrials.gov. Dates move.

Clinical trials (lead sponsor) Showing 50 of 55

Record	Title	Phase	Status	Start	Primary completion
NCT05399537	Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT	Phase 3	Recruiting	Jul 12, 2024	2027-01 (estimated)
NCT07326215	A Study of the Efficacy and Safety of Extracorporeal Carbon Dioxide Removal Using PrismaLung+	Not phased (device or behavioral study)	Recruiting	Dec 11, 2025	Jan 31, 2027 (estimated)
NCT07781124	Clinical Effectiveness and Resource Use in End-Stage Renal Disease Patients: Remote Patient Monitoring Across Dialysis Modalities	Not listed	Recruiting	Jun 17, 2026	Jun 30, 2029 (estimated)
NCT06492031	Observational Study of the Use of Extraneal in Peritoneal Dialysis in Patients	Not listed	Completed	Jun 28, 2024	Jan 27, 2026 (actual)
NCT06983509	Registry of Pre-mixed Solutions in Critically Ill Patients on the Continuous Renal Replacement Therapy	Not listed	Completed	Oct 23, 2024	Sep 11, 2025 (actual)
NCT06633029	Retrospective Analysis of Prismaflex HF20 Set Versus ppCRRT Registry	Not listed	Completed	Dec 11, 2024	Jun 25, 2025 (actual)
NCT01413074	Survival on Peritoneal Dialysis (PD) Versus Hemodialysis (HD) in China	Not phased (device or behavioral study)	Terminated	2011-06	2013-12 (actual)
NCT04617093	Post-Market Study of Low-flow ECCO2R Using PrismaLung+	Not phased (device or behavioral study)	Completed	Apr 30, 2021	Dec 5, 2023 (actual)
NCT00962000	Study of How the Dose of Dialysis is Affected by Dialysate Flow Rate	Not phased (device or behavioral study)	Completed	2009-09	2010-06 (actual)
NCT00659724	Ease of Use and Blood Clotting for the Gambro Polyflux HD-C4 Big Dialyzer	Not listed	Completed	2008-03	2008-05 (actual)
NCT01219959	Dianeal, Extraneal, Nutrineal (D-E-N) Versus Dianeal Only in Diabetic Continuous Ambulatory Peritoneal Dialysis (CAPD) Patients	Phase 3	Completed	2010-10	2011-07 (actual)
NCT02860130	Clinical Evaluation of Use of Prismocitrate 18 in Patients Undergoing Acute Continuous Renal Replacement Therapy (CRRT)	Phase 3	Terminated	Sep 27, 2016	May 12, 2018 (actual)
NCT00567489	IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients	Phase 4	Completed	2008-01	2011-07 (actual)
NCT00567398	IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients	Phase 3	Completed	2008-04	2011-07 (actual)
NCT00368641	Heart Failure and Peritoneal Ultrafiltration	Phase 2	Terminated	2006-08	2008-04 (actual)
NCT02561247	Prismaflex HF20 Set and Prismaflex® System 7.10/7.20 for Acute Continuous Renal Replacement Therapy (CRRT) in Children	Not phased (device or behavioral study)	Terminated	Nov 10, 2015	Apr 6, 2018 (actual)
NCT05309291	Theranova Randomized, Controlled, Trial (RCT) in China	Not phased (device or behavioral study)	Completed	Jun 22, 2022	Jul 6, 2023 (actual)
NCT03812679	Performance Evaluation of the AMIA APD Solution Generation System in Patients End Stage Renal Disease (ESRD)	Not phased (device or behavioral study)	Terminated	Dec 20, 2018	Feb 19, 2020 (actual)
NCT00636077	Comparative Effects Of Dialysate Flow Rate And Membrane Packing On The Performance Of Dialyzers Used For Hemodialysis	Not phased (device or behavioral study)	Completed	2008-02	2008-04 (actual)
NCT03257410	Theranova 400 Dialyzer In End Stage Renal Disease (ESRD) Patients	Not phased (device or behavioral study)	Completed	Sep 29, 2017	Oct 27, 2018 (actual)
NCT00636389	Molecule Removal and Ease of Use: A Comparison of Two Different Dialyzers	Not phased (device or behavioral study)	Completed	2008-02	2008-12 (actual)
NCT01318486	HepZero:Heparin Free Dialysis With Evodial	Not phased (device or behavioral study)	Completed	2011-03	2013-02 (actual)
NCT02377622	Clinical Performance Comparison of 2 THERANOVA 400 Dialyzer Prototypes in HD With High-Flux Dialyzers in HD and hv HDF Mode	Not phased (device or behavioral study)	Completed	2015-02	2015-04 (actual)
NCT01093547	Open-label, Randomized Trial to Determine the Effect of Icodextrin Versus Dextrose (Dianeal 2.5%) in HOMA IR	Phase 4	Withdrawn	2010-02	2011-07 (estimated)
NCT05888376	A Post-Market Clinical Performance and Safety Evaluation of GamCath HighFlow Dolphin Protect Catheter	Not listed	Completed	Dec 7, 2023	Apr 30, 2024 (actual)
NCT00621712	Clinical Assessment of a New Catheter Surface Coating With Antimicrobial Properties	Not phased (device or behavioral study)	Completed	2007-10	2010-12 (actual)
NCT00614146	Recompensation of Exacerbated Liver Insufficiency With Hyperbilirubinemia and/or Encephalopathy and/or Renal Failure	Not phased (device or behavioral study)	Completed	2003-04	2008-01 (actual)
NCT01582893	Permeability Enhancement to Reduce Chronic Inflammation	Not phased (device or behavioral study)	Completed	2012-04	2012-10 (actual)
NCT02084381	PERCI- Medium Cut Off (MCO)	Not phased (device or behavioral study)	Completed	2014-02	2014-07 (actual)
NCT01467180	Myoglobin Removal by High Cut-off CVVHD	Not phased (device or behavioral study)	Completed	2011-11	2014-04 (actual)
NCT03499691	Exploratory Study to Explore the Safety and Efficacy of the HDx Therapy Using Theranova 500 Dialyzer in Comparison to Hemodiafiltration	Not phased (device or behavioral study)	Completed	Apr 11, 2018	Oct 4, 2018 (actual)
NCT01181544	A Pilot Study of a Heparin Dosing Algorithm for Hemodialysis	Not phased (device or behavioral study)	Completed	2011-03	2011-08 (actual)
NCT01579396	High Cut Off Dialysis in Systemic Inflammatory Response Syndrome Patients After Cardiac Surgery	Not phased (device or behavioral study)	Withdrawn	2012-04	2013-09 (estimated)
NCT00621114	Ex Vivo Microbiological Assessment of an Anti-biofilm Catheter in Acute Dialysis Application	Not phased (device or behavioral study)	Completed	2007-08	2009-07 (actual)
NCT02795286	Automated Setting of Individualized Sodium Technology	Not phased (device or behavioral study)	Completed	2016-03	2016-11 (actual)
NCT00922870	Evaluation of Hemodynamic Effects of Cascade Hemofiltration in Septic Shock	Not phased (device or behavioral study)	Completed	2009-04	2013-03 (actual)
NCT00781690	Reduction of Heparin Dose in Dialysis With Evodial System	Not phased (device or behavioral study)	Completed	2008-09	2010-02 (actual)
NCT02377570	Comparison of the Clinical Performance of 3 THERANOVA 400 Dialyzer Prototypes With a High-Flux Dialyzer in Hemodialysis Mode	Not phased (device or behavioral study)	Completed	2015-03	2015-05 (actual)
NCT00875888	High Cut-Off Continuous Veno-venous Hemodialysis (CVVHD) in Patients Treated for Acute Renal Failure After Systemic Inflammatory Response Syndrome (SIRS)/Septic Shock	Not phased (device or behavioral study)	Terminated	2004-02	2009-06 (actual)
NCT01783626	Evaluation of Evodial Hemodialyzer Selectivity Modifications (Evodial +)	Not phased (device or behavioral study)	Completed	2012-10	2013-03 (actual)
NCT03859830	Clinical Observation of the Performance of Artis Dialysis System, ArtiSet PrePost and Ultra HDF Line in Treatments of Patients With End-Stage Renal Disease (ESRD)	Not phased (device or behavioral study)	Completed	Jan 22, 2019	Nov 9, 2019 (actual)
NCT01722695	Performance Comparison of Revaclear With Larger Dialyzer	Not phased (device or behavioral study)	Completed	2012-11	2012-12 (actual)
NCT02378350	Quality of Life on Peritoneal Dialysis Versus Hemodialysis in China	Phase 4	Completed	Mar 26, 2014	Sep 18, 2017 (actual)
NCT01363921	Effect of HCO1100 on Cardiovascular Function	Not phased (device or behavioral study)	Terminated	2011-04	2013-09 (actual)
NCT03547336	Study in End Stage Renal Disease (ESRD) Patients on Hemodialysis Comparing the Theranova Dialyzer to Hemodiafiltration	Not phased (device or behavioral study)	Completed	Jun 29, 2018	Jan 4, 2020 (actual)
NCT01582867	HemoControl System Activated in Hemodiafiltration Treatments	Not phased (device or behavioral study)	Completed	2012-05	2013-05 (actual)
NCT03547323	Study in End Stage Renal Disease (ESRD) Patients on Hemodialysis to Determine Non-inferiority of the Theranova Dialyzer Compared to the FX80 Dialyzer	Not phased (device or behavioral study)	Completed	Sep 14, 2018	Jun 14, 2019 (actual)
NCT01526798	Improvement of EPO-resistance in Hemodialysis Patients With Chronic Inflammation by High Cut-off Hemodialysis	Not phased (device or behavioral study)	Completed	2012-03	2012-11 (actual)
NCT00804453	Evaluation of the Biocompatibility of Cartridge Blood Set Versus Standard Blood Line	Not phased (device or behavioral study)	Completed	2008-11	2008-11 (actual)
NCT00579202	Ease of Use Study for the Gambro Polyflux HD-C4 Small Dialyzer	Not listed	Completed	2007-10	2007-11 (actual)

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