COMPANY

MTI Biotech Inc

HQ: Ames, IA source · mtibiotech.com ↗ · Midwest

Location: Ames, IA · source · Oct 15, 2026

Profile checked Oct 10, 2026

Keywords: pulmonary hypertension Alzheimer Disease Mild Cognitive Impairment alzheimer's disease 2-hydroxybenzylamine

Timeline

Sep 1, 2026 Trial start Phase 1/Phase 2: 2-Hydroxybenzylamine (2-HOBA) Study in Early Alzheimer's Patients source ↗
Aug 15, 2025 Grant Government grant — STTR: $957,913 (annual award, as published), announced Aug 15, 2025. Agency: NIH/NHLBI. Source: government award database. source ↗

Dec 30, 2028 (ESTIMATED) · Phase 1/Phase 2 · 2-Hydroxybenzylamine (2-HOBA) Study in Early Alzheimer's Patients · NCT06432166

Estimated primary completion per ClinicalTrials.gov. Dates move.

Last 2 years.

Aug 15, 2025 Government grant — STTR: $957,913 (annual award, as published), announced Aug 15, 2025. Agency: NIH/NHLBI. Source: government award database. source ↗

Record	Title	Phase	Status	Start	Primary completion
NCT06432166	2-Hydroxybenzylamine (2-HOBA) Study in Early Alzheimer's Patients	Phase 1/Phase 2	Not yet recruiting	Sep 1, 2026	Dec 30, 2028 (estimated)

Annual award amounts. Total $3.4M.

Aug 30, 2024 NIH award 5R42HL158393-03 FY2024: $957,913 awarded for that fiscal year; activity R42 (STTR); PI RATHMACHER, JOHN A; recipient as written: MTI BIOTECH, INC., AMES, IA. 2-HOBA for Treatment of Pulmonary Hypertension source ↗
Aug 23, 2023 NIH award 2R42HL158393-02 FY2023: $1,173,060 awarded for that fiscal year; activity R42 (STTR); PI RATHMACHER, JOHN A; recipient as written: MTI BIOTECH, INC., AMES, IA. 2-HOBA for Treatment of Pulmonary Hypertension source ↗
Jul 26, 2021 NIH award 1R41HL158393-01 FY2021: $256,580 awarded for that fiscal year; activity R41 (STTR); PI RATHMACHER, JOHN A; recipient as written: MTI BIOTECH, INC., AMES, IA. 2-HOBA for Treatment of Pulmonary Hypertension source ↗
Apr 8, 2021 NIH award 1R41CA257262-01A1 FY2021: $400,000 awarded for that fiscal year; activity R41 (STTR); PI RATHMACHER, JOHN A; recipient as written: MTI BIOTECH, INC., AMES, IA. Efficacy of an Electrophile Scavenger in the P source ↗
Jul 8, 2019 NIH award 6R44AG055184-03 FY2017: $605,216 awarded for that fiscal year; activity R44 (SBIR); PI RATHMACHER, JOHN A; recipient as written: MTI BIOTECH, INC., AMES, IA. 2-Hydroxybenzylamine for the prevention of Alzhe source ↗