COMPANY

Trevena

Keywords: neurology migraine opioid use disorder Acute Pain Heart Failure Migraines Acute Decompensated Heart Failure Kidney Disease TRV130 TRV120027 TRV734 TRV130A

Location: Atlanta, GA · source · Oct 15, 2026

Profile checked Oct 10, 2026

16Trials (company is sponsor)

Timeline

Nov 11, 2019 Trial start Phase 1: A Trial to Evaluate the Efficacy, Safety and Tolerability of Subcutaneous TRV250 source ↗
2016-05 Trial start Phase 3: Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty source ↗
2016-05 Trial start Phase 3: Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Bunionectomy source ↗
2015-12 Trial start Phase 3: A Open-label Study to Evaluate the Safety of TRV130 in Patients With Acute Pain source ↗
Oct 20, 2015 Trial start Phase 2: A Pilot Study of TRV130 for the Treatment of Fracture Pain source ↗
2015-02 Trial start Phase 1: A Pharmacokinetic, Safety and Tolerability Study in Healthy Adult Males source ↗
2014-12 Trial start Phase 2: A Study of TRV130 for the Treatment of Pain After Abdominoplasty source ↗
2014-12 Trial start Phase 1: Study of the Effects of TRV130, at Therapeutic and Supra Therapeutic Doses, on QTc Intervals source ↗
2014-07 Trial start Phase 1: A Safety, Tolerability, PD and PK Study in Healthy Adults source ↗
2014-06 Trial start Phase 1: A Study to Investigate the Metabolism and Excretion of [14C]-TRV130 in Healthy Male Subjects source ↗
2014-04 Trial start Phase 2: A Study of TRV130 for the Treatment of Pain After Bunionectomy source ↗
2013-12 Trial start Phase 2: A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure source ↗
2013-07 Trial start Phase 1: Pharmacokinetics and Pharmacodynamics of TRV130, Morphine, and Placebo in Healthy Subjects source ↗
2012-01 Trial start Phase 1: Single Ascending Dose Study of Intravenous TRV130A in Healthy Adult Males source ↗
2011-08 Trial start Phase 1: Study to Evaluate TRV120027 on Renal Pharmacodynamics in Patients With Heart Failure and Renal Dysfunction source ↗
2010-12 Trial start Phase 1/Phase 2: Study to Evaluate the Effects of TRV120027 in Patients With Heart Failure source ↗

Clinical trials (lead sponsor) 16

Record	Title	Phase	Status	Start	Primary completion
NCT04201080	A Trial to Evaluate the Efficacy, Safety and Tolerability of Subcutaneous TRV250	Phase 1	Terminated	Nov 11, 2019	Feb 17, 2020 (actual)
NCT02820324	Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty	Phase 3	Completed	2016-05	2016-12 (actual)
NCT02815709	Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Bunionectomy	Phase 3	Completed	2016-05	2016-12 (actual)
NCT02656875	A Open-label Study to Evaluate the Safety of TRV130 in Patients With Acute Pain	Phase 3	Completed	2015-12	2017-05 (actual)
NCT02100748	A Study of TRV130 for the Treatment of Pain After Bunionectomy	Phase 2	Completed	2014-04	2014-10 (actual)
NCT02335294	A Study of TRV130 for the Treatment of Pain After Abdominoplasty	Phase 2	Completed	2014-12	2015-07 (actual)
NCT02520297	A Pilot Study of TRV130 for the Treatment of Fracture Pain	Phase 2	Terminated	Oct 20, 2015	Oct 23, 2015 (actual)
NCT01966601	A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure	Phase 2	Completed	2013-12	2016-03 (actual)
NCT01187836	Study to Evaluate the Effects of TRV120027 in Patients With Heart Failure	Phase 1/Phase 2	Completed	2010-12	2012-03 (actual)
NCT02344303	Study of the Effects of TRV130, at Therapeutic and Supra Therapeutic Doses, on QTc Intervals	Phase 1	Completed	2014-12	2015-05 (actual)
NCT02169934	A Study to Investigate the Metabolism and Excretion of [14C]-TRV130 in Healthy Male Subjects	Phase 1	Completed	2014-06	2015-01 (actual)
NCT02411500	A Pharmacokinetic, Safety and Tolerability Study in Healthy Adult Males	Phase 1	Completed	2015-02	2015-03 (actual)
NCT02211625	A Safety, Tolerability, PD and PK Study in Healthy Adults	Phase 1	Completed	2014-07	2014-10 (actual)
NCT02083315	Pharmacokinetics and Pharmacodynamics of TRV130, Morphine, and Placebo in Healthy Subjects	Phase 1	Completed	2013-07	2013-08 (actual)
NCT01444872	Study to Evaluate TRV120027 on Renal Pharmacodynamics in Patients With Heart Failure and Renal Dysfunction	Phase 1	Completed	2011-08	2012-05 (actual)
NCT01514578	Single Ascending Dose Study of Intravenous TRV130A in Healthy Adult Males	Phase 1	Completed	2012-01	2012-07 (actual)