COMPANY

Exact Sciences

HQ: Madison, WI source · exactsciences.com ↗ · Midwest

Profile checked Oct 10, 2026

Keywords: Colorectal Cancer Colorectal Neoplasms Digestive System Diseases Colonic Diseases Breast Cancer Hepatocellular Carcinoma Liver Cancer Colo-rectal Cancer Abnormal Uterine Bleeding Endometrial Cancer Atypical Endometrial Hyperplasia Endometrial Hyperplasia With Atypia Endometrial Intraepithelial Neoplasia Hepatocellular Cancer Hepatitis B Cirrhosis Colon Cancer Early Cancer Detection COVID-19 Lung Cancer Prostate Cancer Bladder Cancer Uterine Cancer Kidney Cancer Renal Pelvis Cancer Pancreatic Cancer Stomach Cancer Ovarian Cancer Esophageal Cancer Lung Cancer (Diagnosis) Melanoma Hematologic Malignancy Hepatocellular Carcinoma Surveillance Colorectal Cancer Screening Inflammatory Bowel Disease Primary Sclerosing Cholangitis Cologuard Exact Sciences Multicancer Early Detection (MCED) Test

31Trials (company is sponsor)

Timeline

Mar 10, 2026 Trial start —: Endometrial Cancer Vaginal Fluid Specimen Collection Study source ↗
Aug 1, 2024 Trial start —: Falcon Real World Evidence Registry source ↗
Jun 7, 2024 Trial start —: EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD) source ↗
Jun 20, 2023 Trial start —: First CORRECT Study of Minimal Residual Disease (MRD) Detection in Colorectal Cancer source ↗
Apr 28, 2022 Trial start —: Informed Choice - Compass source ↗
Dec 15, 2021 Trial start —: CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer source ↗
Jul 26, 2021 Trial start —: ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk source ↗
Jul 21, 2020 Trial start —: Stool Collection Sub-Study of Exact Sciences Protocol 2018-01 source ↗
May 18, 2020 Trial start —: Home Usability Study of the SARS-CoV-2 (COVID-19) Test source ↗
Nov 18, 2019 Trial start —: Detecting Cancers Earlier Through Elective Plasma-based CancerSEEK Testing source ↗
Nov 15, 2019 Trial start —: Blood Collection Sub-Study of Exact Sciences Protocol 2019-01: "Clinical Validation of an Optimized Multi-Target Stool DNA (Mt-sDNA 2.0) Test, For Colorectal Cancer Screening BLUE-C" source ↗
Nov 15, 2019 Trial start —: Clinical Validation of An Optimized Multi-Target Stool DNA (Mt-sDNA 2.0) Test, for Colorectal Cancer Screening "BLUE-C" source ↗
Oct 18, 2019 Trial start —: Voyage: Real-World Impact of the Multi-target Stool DNA Test on CRC Screening and Mortality source ↗
Jan 10, 2019 Trial start —: Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Melanoma source ↗
Jan 3, 2019 Trial start —: Blood and Stool Sample Collection in Subjects Participating in Colorectal Cancer Screening: Act Bold source ↗
Dec 20, 2018 Trial start —: Blood and Stool Sample Collection in Subjects With a Diagnosis of Colorectal Cancer or Colorectal Lesion: Act Fast source ↗
Dec 7, 2018 Trial start —: Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Hematologic Malignancies source ↗
Nov 8, 2018 Trial start —: Blood Collection Sub-Study for CRC Screening in Individuals 45-49 at Average Risk for CRC. source ↗
Nov 6, 2018 Trial start —: An Evaluation of a Multi-target Stool DNA (Mt-sDNA) Test, Cologuard, for CRC Screening in Individuals Aged 45-49 and at Average Risk for Development of Colorectal Cancer: Act Now source ↗
Oct 30, 2018 Trial start —: Observational Study of Sub-populations From Cologuard Post-Approval Study (2014-01) source ↗
Aug 23, 2018 Trial start —: Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Solid Tumors source ↗
Apr 2, 2018 Trial start —: Blood Sample Collection to Evaluate Biomarkers for Hepatocellular Carcinoma source ↗
Apr 6, 2017 Trial start —: Blood Sample Collection in Subjects Participating in a Lung Cancer Screening Program source ↗
Apr 11, 2016 Trial start —: Blood Sample Collection in Subjects With Pulmonary Nodules or CT Suspicion of Lung Cancer or Pathologically Diagnosed Lung Cancer source ↗
2015-04 Trial start —: A Study of Cologuard™ in an Average Risk Population Assessing a Three Year Test Interval source ↗

Showing 25 of 31 dated events.

Upcoming milestones

May 15, 2027 (ESTIMATED) · · CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer · NCT05210283
2027-09 (ESTIMATED) · · First CORRECT Study of Minimal Residual Disease (MRD) Detection in Colorectal Cancer · NCT06398743
Apr 24, 2028 (ESTIMATED) · · Endometrial Cancer Vaginal Fluid Specimen Collection Study · NCT07544680
2030-04 (ESTIMATED) · · EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD) · NCT06401421
2030-08 (ESTIMATED) · · Falcon Real World Evidence Registry · NCT06589310

Estimated primary completion per ClinicalTrials.gov. Dates move.

Clinical trials (lead sponsor) 31

Record	Title	Phase	Status	Start	Primary completion
NCT07544680	Endometrial Cancer Vaginal Fluid Specimen Collection Study	Not listed	Active, not recruiting	Mar 10, 2026	Apr 24, 2028 (estimated)
NCT06589310	Falcon Real World Evidence Registry	Not listed	Recruiting	Aug 1, 2024	2030-08 (estimated)
NCT06401421	EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)	Not listed	Recruiting	Jun 7, 2024	2030-04 (estimated)
NCT05210283	CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer	Not listed	Active, not recruiting	Dec 15, 2021	May 15, 2027 (estimated)
NCT05246839	Informed Choice - Compass	Not listed	Terminated	Apr 28, 2022	Jan 31, 2025 (actual)
NCT05064553	ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk	Not listed	Active, not recruiting	Jul 26, 2021	Sep 12, 2025 (actual)
NCT04124406	Voyage: Real-World Impact of the Multi-target Stool DNA Test on CRC Screening and Mortality	Not listed	Active, not recruiting	Oct 18, 2019	Dec 31, 2023 (actual)
NCT06398743	First CORRECT Study of Minimal Residual Disease (MRD) Detection in Colorectal Cancer	Not listed	Active, not recruiting	Jun 20, 2023	2027-09 (estimated)
NCT03789162	Blood and Stool Sample Collection in Subjects With a Diagnosis of Colorectal Cancer or Colorectal Lesion: Act Fast	Not listed	Completed	Dec 20, 2018	Mar 31, 2025 (actual)
NCT04213326	Detecting Cancers Earlier Through Elective Plasma-based CancerSEEK Testing	Not listed	Completed	Nov 18, 2019	Jan 29, 2021 (actual)
NCT04395391	Home Usability Study of the SARS-CoV-2 (COVID-19) Test	Not listed	Completed	May 18, 2020	May 21, 2020 (actual)
NCT04144751	Blood Collection Sub-Study of Exact Sciences Protocol 2019-01: "Clinical Validation of an Optimized Multi-Target Stool DNA (Mt-sDNA 2.0) Test, For Colorectal Cancer Screening BLUE-C"	Not listed	Completed	Nov 15, 2019	Mar 30, 2023 (actual)
NCT04144738	Clinical Validation of An Optimized Multi-Target Stool DNA (Mt-sDNA 2.0) Test, for Colorectal Cancer Screening "BLUE-C"	Not listed	Completed	Nov 15, 2019	Mar 30, 2023 (actual)
NCT03662204	Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Solid Tumors	Not listed	Completed	Aug 23, 2018	Mar 31, 2022 (actual)
NCT04473625	Stool Collection Sub-Study of Exact Sciences Protocol 2018-01	Not listed	Completed	Jul 21, 2020	Mar 31, 2022 (actual)
NCT03728348	An Evaluation of a Multi-target Stool DNA (Mt-sDNA) Test, Cologuard, for CRC Screening in Individuals Aged 45-49 and at Average Risk for Development of Colorectal Cancer: Act Now	Not listed	Completed	Nov 6, 2018	Jun 18, 2019 (actual)
NCT03741166	Blood Collection Sub-Study for CRC Screening in Individuals 45-49 at Average Risk for CRC.	Not listed	Completed	Nov 8, 2018	Apr 5, 2019 (actual)
NCT03628638	Blood Sample Collection in Subjects Participating in a Lung Cancer Screening Program	Not listed	Completed	Apr 6, 2017	Jan 31, 2021 (actual)
NCT03633006	Blood Sample Collection in Subjects With Pulmonary Nodules or CT Suspicion of Lung Cancer or Pathologically Diagnosed Lung Cancer	Not listed	Completed	Apr 11, 2016	Dec 31, 2020 (actual)
NCT03727087	Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Melanoma	Not listed	Terminated	Jan 10, 2019	Mar 24, 2020 (actual)
NCT03727009	Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Hematologic Malignancies	Not listed	Terminated	Dec 7, 2018	Mar 24, 2020 (actual)
NCT03628651	Blood Sample Collection to Evaluate Biomarkers for Hepatocellular Carcinoma	Not listed	Completed	Apr 2, 2018	Mar 11, 2020 (actual)
NCT03821948	Blood and Stool Sample Collection in Subjects Participating in Colorectal Cancer Screening: Act Bold	Not listed	Completed	Jan 3, 2019	Feb 28, 2020 (actual)
NCT03705013	Observational Study of Sub-populations From Cologuard Post-Approval Study (2014-01)	Not listed	Terminated	Oct 30, 2018	Nov 16, 2019 (actual)
NCT02419716	A Study of Cologuard™ in an Average Risk Population Assessing a Three Year Test Interval	Not listed	Completed	2015-04	Mar 16, 2020 (actual)
NCT02503631	Stool Sample Collection Protocol for Development of Screening Test for Colorectal Cancer and Other Digestive Tract Cancers	Not listed	Terminated	2014-10	2017-03 (actual)
NCT01819766	Detection of Advanced Colorectal Neoplasia by Stool DNA in Inflammatory Bowel Disease	Not listed	Completed	2013-03	2017-01 (actual)
NCT02503696	Sample Collection Study to Evaluate DNA Markers in Subjects With Inflammatory Bowel Disease (IBD)	Not listed	Completed	2014-09	2015-11 (actual)
NCT01397747	Multi-Target Colorectal Cancer Screening Test for the Detection of Colorectal Advanced Adenomatous Polyps and Cancer	Not listed	Completed	2011-06	2013-02 (actual)
NCT01600209	Exact CRC Screening Test: Stool Sample Collection Study to Support Assay Validation Testing	Not listed	Completed	2011-10	2012-08 (actual)
NCT01260168	Multi-marker Stool Test for Detection of Colorectal Neoplasia: Marker Panel Selection and Technical Development Studies	Not listed	Completed	2010-10	2013-11 (actual)