COMPANY

Xylyx Bio

HQ: Brooklyn, NY source · xylyxbio.com ↗ · Mid-Atlantic

Location: Brooklyn, NY · source · Oct 15, 2026

Profile checked Oct 10, 2026

10NIH grants

Funding and NIH signals

NIH award NIH awarded $957K (SBIR Phase II 5R44DK139877-03, continuation, notice Sep 10, 2026); 3 NIH awards totaling $3.44M in the last 12 months. NIH RePORTER 5R44DK139877-03 (Sep 10, 2026)
Evidence (3 events)
- Sep 10, 2026 · NIH RePORTER 5R44DK139877-03
  Organization: XYLYX BIO, INC.; City/State: BROOKLYN, NY; Project number: 5R44DK139877-03; Activity code: R44; Fiscal year: 2026; Award notice date: 2026-09-10; FY total cost (award amount): 956566; Administering IC: National Institute of Diabetes and Digestive and Kidney Diseases; Project title: Liver fibrosis cell-based assay platform: integrating patient-derived fibrotic liver ECM with primary stellate cells, Kupffer cells, and hepatocytes to accelerate anti-fibrotic drug development; Organization type: Domestic For-Profits
- Aug 7, 2026 · NIH RePORTER 5R44HL182545-02
  Organization: XYLYX BIO, INC.; City/State: BROOKLYN, NY; Project number: 5R44HL182545-02; Activity code: R44; Fiscal year: 2026; Award notice date: 2026-08-07; FY total cost (award amount): 1483340; Administering IC: National Heart Lung and Blood Institute; Project title: Translational development and clinical evaluation of a bioengineered human lung graft for clinical transplantation; Organization type: Domestic For-Profits
- Jul 23, 2026 · NIH RePORTER 5R44CA287881-03
  Organization: XYLYX BIO, INC.; City/State: BROOKLYN, NY; Project number: 5R44CA287881-03; Activity code: R44; Fiscal year: 2026; Award notice date: 2026-07-23; FY total cost (award amount): 1003395; Administering IC: National Cancer Institute; Project title: Multi-organ metastatic breast cancer cell-based assay platform that models organotropic metastases using patient organoids in human tissue-derived ECMs to accelerate anti-metastatic drug development; Organization type: Domestic For-Profits

Job counts as of Oct 18, 2026. All funding and NIH signals

Timeline

Sep 10, 2026 Grant Government grant — SBIR: $956,566 (annual award, as published), announced Sep 10, 2026. Agency: NIH/NIDDK. Source: government award database. source ↗
Aug 7, 2026 Grant Government grant — SBIR: $1.48M (annual award, as published), announced Aug 7, 2026. Agency: NIH/NHLBI. Source: government award database. source ↗
Jul 23, 2026 Grant Government grant — SBIR: $1M (annual award, as published), announced Jul 23, 2026. Agency: NIH/NCI. Source: government award database. source ↗
Sep 10, 2025 Grant Government grant — SBIR: $967,715 (annual award, as published), announced Sep 10, 2025. Agency: NIH/NIDDK. Source: government award database. source ↗
Sep 5, 2025 Grant Government grant — SBIR: $1.52M (annual award, as published), announced Sep 5, 2025. Agency: NIH/NHLBI. Source: government award database. source ↗
Jun 12, 2025 Grant Government grant — SBIR: $966,420 (annual award, as published), announced Jun 12, 2025. Agency: NIH/NCI. Source: government award database. source ↗

Funding

Last 2 years.

Sep 10, 2026 Government grant — SBIR: $956,566 (annual award, as published), announced Sep 10, 2026. Agency: NIH/NIDDK. Source: government award database. source ↗
Aug 7, 2026 Government grant — SBIR: $1.48M (annual award, as published), announced Aug 7, 2026. Agency: NIH/NHLBI. Source: government award database. source ↗
Jul 23, 2026 Government grant — SBIR: $1M (annual award, as published), announced Jul 23, 2026. Agency: NIH/NCI. Source: government award database. source ↗
Sep 10, 2025 Government grant — SBIR: $967,715 (annual award, as published), announced Sep 10, 2025. Agency: NIH/NIDDK. Source: government award database. source ↗
Sep 5, 2025 Government grant — SBIR: $1.52M (annual award, as published), announced Sep 5, 2025. Agency: NIH/NHLBI. Source: government award database. source ↗
Jun 12, 2025 Government grant — SBIR: $966,420 (annual award, as published), announced Jun 12, 2025. Agency: NIH/NCI. Source: government award database. source ↗

NIH awards 10

Annual award amounts. Total $3.6M.

Aug 23, 2024 NIH award 1R44DK139877-01A1 FY2024: $370,020 awarded for that fiscal year; activity R44 (SBIR); PI O'NEILL, JOHN DAVID; recipient as written: XYLYX BIO, INC., BROOKLYN, NY. Liver fibrosis cell-based assay platform: i source ↗
Jun 6, 2024 NIH award 1R44CA287881-01A1 FY2024: $295,604 awarded for that fiscal year; activity R44 (SBIR); PI O'NEILL, JOHN DAVID; recipient as written: XYLYX BIO, INC., BROOKLYN, NY. Multi-organ metastatic breast cancer cell-b source ↗
Jun 6, 2023 NIH award 3R44HL158364-03S1 FY2023: $109,343 awarded for that fiscal year; activity R44 (SBIR); PI O'NEILL, JOHN DAVID; recipient as written: XYLYX BIO, INC., BROOKLYN, NY. Lung fibrosis modeling and compound testing source ↗
Mar 10, 2023 NIH award 5R44HL158364-03 FY2023: $961,355 awarded for that fiscal year; activity R44 (SBIR); PI O'NEILL, JOHN DAVID; recipient as written: XYLYX BIO, INC., BROOKLYN, NY. Lung fibrosis modeling and compound testing p source ↗
Nov 25, 2022 NIH award 3R44HL158364-02S1 FY2023: $70,024 awarded for that fiscal year; activity R44 (SBIR); PI O'NEILL, JOHN DAVID; recipient as written: XYLYX BIO, INC., BROOKLYN, NY. Lung fibrosis modeling and compound testing source ↗
Apr 13, 2022 NIH award 4R44HL158364-02 FY2022: $950,532 awarded for that fiscal year; activity R44 (SBIR); PI O'NEILL, JOHN DAVID; recipient as written: XYLYX BIO, INC., BROOKLYN, NY. Lung fibrosis modeling and compound testing p source ↗
Aug 31, 2021 NIH award 1R44HL158364-01A1 FY2021: $297,924 awarded for that fiscal year; activity R44 (SBIR); PI O'NEILL, JOHN DAVID; recipient as written: XYLYX BIO, INC., BROOKLYN, NY. Lung fibrosis modeling and compound testing source ↗
May 22, 2020 NIH award 1R43HL150991-01A1 FY2020: $224,101 awarded for that fiscal year; activity R43 (SBIR); PI O'NEILL, JOHN DAVID; recipient as written: XYLYX BIO, INC., BROOKLYN, NY. Biomimetic lung sealant to rapidly heal pul source ↗
Feb 11, 2019 NIH award 3R43HL144341-01A1S1 FY2019: $54,875 awarded for that fiscal year; activity R43 (SBIR); PI O'NEILL, JOHN DAVID; recipient as written: XYLYX BIO, INC., BROOKLYN, NY. Native cell specific microenvironments for source ↗
Sep 12, 2018 NIH award 1R43HL144341-01A1 FY2018: $224,566 awarded for that fiscal year; activity R43 (SBIR); PI O'NEILL, JOHN DAVID; recipient as written: XYLYX BIO, INC., BROOKLYN, NY. Fibrotic lung extracellular matrix cell cul source ↗